Detoxification Benefits of Chlorophyll and Chlorella

A close up image of chlorophyll.

Chlorophyll and chlorella are well-regarded as being supportive of the body's natural detoxification processes and overall health. While they are frequently grouped together, there are important distinctions between these two nutrients.

Chlorophyll and chlorella are two nutrients that are often utilized for their detoxifying properties. While chlorophyll and chlorella are similar, they are not the same. This article explains the differences and similarities between chlorophyll and chlorella, their potential benefits, and their mechanisms of action in the body. It also shares some practical ways to incorporate these nutrients into your wellness routine.

What’s the Difference Between Chlorophyll & Chlorella?

Chlorophyll and chlorella are similar, but they are not the same: While chlorophyll is an isolated compound, chlorella is an algae that contains chlorophyll as one of its primary components.


Chlorophyll


You might remember the term chlorophyll from biology class—it's the green pigment that allows plants and algae to carry out photosynthesis, the process of converting sunlight into energy. As a plant extract, chlorophyll is known to support detoxification (1) and healthy oxygen uptake (2,3) and is commonly consumed as a liquid supplement.

Chlorella


Chlorella, a single-celled freshwater algae, is widely regarded as a superfood. It boasts one of the highest concentrations of chlorophyll found in any plant on Earth (4). As a whole food, it also provides a variety of vitamins, minerals, and antioxidants (4).


Chlorella is available as a supplement in various forms, including powders, tablets, and in herbal glycerites. Chlorella has an exceptionally hard cell wall, so it is most beneficial when consumed in a form where the cell wall has been broken or processed to enhance bioavailability (5).

How Do Chlorophyll and Chlorella Support Detoxification?

Both chlorophyll and chlorella are powerful tools for supporting effective detoxification. Here’s how they support the body’s natural detox processes:


1. Bind and Neutralize Toxins


Chlorophyll is particularly noted for its potential to bind with certain substances, such as endocrine disruptors (1) and aflatoxins (6). By binding to these substances, chlorophyll may help reduce their absorption in the gut and promote their effective excretion from the body. Similarly, chlorella has been studied for its ability to bind to and facilitate the excretion of heavy metals from the body (7,8,9).


To learn more about detoxification, read this article: How Does Detoxification Work? Understanding Phase I, Phase II, and Phase III Detoxification.


2. Support Liver Function


Chlorella and chlorophyll may support overall liver health when used as part of a balanced diet and healthy lifestyle (10,11). Research on chlorella supplementation in individuals with non-alcoholic fatty liver disease have observed reductions in liver enzyme levels as well as improvements in blood sugar and lipid profiles (10). These potential benefits could be associated with chlorella’s nutrient density and chlorophyll content.


Castor oil packs are another great way to support liver health. To learn more, read this article: Castor Oil Packs: A Natural Remedy For Liver Health and Detoxification.


3. Neutralize Free Radicals and Reduce Oxidative Stress


Chlorophyll and chlorella are sources of antioxidants, which may help neutralize free radicals and reduce oxidative stress (12,13,14). This antioxidant support can assist in maintaining the health of detoxification organs, such as the liver, and promote efficient detoxification processes.


To learn more about how antioxidants work, read this article: Everything You Need To Know About Antioxidants.


4. Support Healthy Oxygenation


Both chlorophyll and chlorella are thought to support healthy oxygenation within the body. Chlorophyll’s structure closely resembles hemoglobin (15), the molecule in red blood cells responsible for oxygen transport, and may assist in promoting efficient oxygen uptake (16). Healthy oxygenation supports detoxification by enhancing the delivery of oxygen to cells and tissues (17), which is essential for optimal metabolic and detox processes. Healthy oxygenation is important for energy levels, cellular health, and overall vitality.


5. Promote Natural Deodorization


Chlorophyll and chlorella have been noted for their potential to reduce odors by neutralizing odor-causing compounds in the body. Historically, chlorophyllin, a derivative of chlorophyll, was used to manage wound and fecal odors (18,19). Chlorophyllin has also been studied for its effectiveness in reducing the "fishy" odor associated with trimethylaminuria, a condition marked by the excretion of trimethylamine (20). While chlorella's role in deodorization is less studied, its high chlorophyll content suggests it may have similar benefits, and anecdotally, many people reach for chlorella to help with occasional bad breath and body odor.

Who Should Use Chlorophyll or Chlorella Supplements?

Chlorophyll and chlorella are suitable for a wide range of individuals and although large scale studies are lacking, these supplements are generally regarded as being quite safe even for children, provided they are well-tolerated and given in age-appropriate dosages.


Naturopathic doctors often recommend chlorophyll or chlorella supplements for individuals looking to support detoxification, liver health, blood oxygenation, and antioxidant protection.


To learn more about how to choose supplements for your family, read these articles: How To Create A Daily Supplement Protocol For Your Family and How To Calculate Supplement Dosages For Kids.

A woman smiles while eating a salad.

How To Take Chlorophyll and Chlorella Supplements?

Chlorophyll and chlorella can be consumed in various forms, making them easy to incorporate into a daily wellness routine. Liquid chlorophyll is one of the most popular methods and is commonly added to water, tea, or juice. Starting the day with a morning glass of water mixed with chlorophyll glycerite offers a refreshing and effective way to support daily detoxification!


Chlorella is frequently used in powder form, often as an addition to smoothies for a nutrient boost. You can also find chlorella in tablets and as a glycerite. Chlorella is a key ingredient in two of our detox-focused supplements: VaxClear™ and Metal Mend™.


To learn more about choosing the right supplement form, read this article: Choosing A Supplement Delivery Method For Your Family.

Who Shouldn’t Take Chlorophyll or Chlorella Supplements?

While chlorophyll and chlorella are generally well-tolerated, they may not be suitable for everyone. It’s important to consider individual circumstances and consult with a healthcare provider if needed. Here are some scenarios where caution may be necessary:

  1. Allergies: Individuals with known allergies to algae should avoid chlorella and chlorophyll.

  2. Medication Interactions: Chlorophyll and chlorella may bind to certain medications, potentially reducing their effectiveness. This is particularly important for medications requiring consistent blood levels, such as blood thinners, immunosuppressants, and thyroid medications.

  3. Digestive Sensitivities: Some people may experience mild digestive discomfort, such as bloating or gas, when starting chlorophyll or chlorella (21). Chlorophyll and chlorella may turn the feces and urine green and may stain the mouth. This is not a cause for concern. Gradual introduction is recommended to assess tolerance, and if digestive upset occurs, supplementation should be stopped or slowed to a tolerable dose.

Moderate doses of chlorophyll and chlorella are generally considered safe for consumption during pregnancy and lactation (21), with some studies indicating potential benefits. For example, chlorella supplementation has been linked to a reduced risk of anemia, edema, and proteinuria in pregnant women (22). However, comprehensive research on their safety and efficacy during pregnancy and lactation remains limited. Therefore, it is advisable for pregnant and breastfeeding women to consult with their healthcare provider before incorporating chlorophyll or chlorella supplements into their regimen.

Summary

Chlorophyll and chlorella are well-regarded as being supportive of the body's natural detoxification processes and overall health. While they are frequently grouped together, there are important distinctions between these two nutrients.


Chlorophyll is an isolated plant compound that supports detoxification, oxygenation, and liver health and is commonly consumed in liquid form.


Chlorella is a nutrient-dense freshwater algae that has a high chlorophyll content. Being a whole food, it also contains additional vitamins, minerals, and antioxidants, making it a popular choice for those seeking to support healthy detoxification and overall wellness.


Both are generally well-tolerated and versatile, but certain individuals, including those with allergies or taking prescription medications, should consult a healthcare provider before use. 

PRODUCTS MENTIONED IN THIS ARTICLE

References:

  1. Martins T, Barros AN, Rosa E, Antunes L. (2023). Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review. Molecules. Jul 11;28(14):5344. doi: 10.3390/molecules28145344. PMID: 37513218; PMCID: PMC10384064.

  2. Tagauov YD, Abu-Elsaoud AM, Abdrassulova ZT, Tuleukhanov ST, Salybekova NN, Tulindinova G, Al-Abkal F. Improvement of Blood Parameters of Male Rats Exposed to Different Injection Doses of Liquid Chlorophyll. Cureus. 2023 Mar 12;15(3):e36044. doi: 10.7759/cureus.36044. PMID: 37056524; PMCID: PMC10089374.

  3. Patek AJ. (1936). Chlorophyll and regeneration of the blood: Effect of administration of Chlorophyll derivatives to patients with Chronic Hypochromic Anemia. Arch Intern Med (Chic). 1936;57(1):73–84. doi:10.1001/archinte.1936.00170050081006

  4. Bito T, Okumura E, Fujishima M, Watanabe F. (2020). Potential of Chlorella as a Dietary Supplement to Promote Human Health. Nutrients. Aug 20;12(9):2524. doi: 10.3390/nu12092524. PMID: 32825362; PMCID: PMC7551956.

  5. Wu Q, Ma Y, Zhang L, Han J, Lei Y, Le Y, Huang C, Kan J, Fu C. (20023). Extraction, functionality, and applications of Chlorella pyrenoidosa protein/peptide. Curr Res Food Sci. Oct 26;7:100621. doi: 10.1016/j.crfs.2023.100621. PMID: 38021256; PMCID: PMC10653999.

  6. Jubert C, Mata J, Bench G, Dashwood R, Pereira C, Tracewell W, Turteltaub K, Williams D, Bailey G. (2009). Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer Prev Res (Phila). Dec;2(12):1015-22. doi: 10.1158/1940-6207.CAPR-09-0099. Epub 2009 Dec 1. PMID: 19952359; PMCID: PMC5314947.

  7. Uchikawa T, Kumamoto Y, Maruyama I, Kumamoto S, Ando Y, Yasutake A. (2011). Enhanced elimination of tissue methylmercury in Parachlorella beijerinckii-fed mice. J Toxicol Sci. Jan;36(1):121-6. doi: 10.2131/jts.36.121. PMID: 21297350.

  8. Ran Y, Sun D, Liu X, Zhang L, Niu Z, Chai T, Hu Z, & Qiao K. (2024). Chlorella pyrenoidosa as a potential bioremediator: Its tolerance and molecular responses to cadmium and lead. Science of the Total Environment, 912, 168712–168712. https://doi.org/10.1016/j.scitotenv.2023.168712

  9. Merino JJ, Parmigiani-Izquierdo JM, Toledano Gasca A, Cabaña-Muñoz ME. (2019). The Long-Term Algae Extract (Chlorella and Fucus sp) and Aminosulphurate Supplementation Modulate SOD-1 Activity and Decrease Heavy Metals (Hg++, Sn) Levels in Patients with Long-Term Dental Titanium Implants and Amalgam Fillings Restorations. Antioxidants (Basel). Apr 16;8(4):101. doi: 10.3390/antiox8040101. PMID: 31014007; PMCID: PMC6523211.

  10. Ebrahimi-Mameghani M, Aliashrafi S, Javadzadeh Y, AsghariJafarabadi M. (2014). The Effect of Chlorella vulgaris Supplementation on Liver En-zymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease. Health Promot Perspect. Jul 12;4(1):107-15. doi: 10.5681/hpp.2014.014. PMID: 25097844; PMCID: PMC4122038.

  11. Yang Y, Jiang X, Pandol SJ, Han YP, Zheng X. (2021). Green Plant Pigment, Chlorophyllin, Ameliorates Non-alcoholic Fatty Liver Diseases (NAFLDs) Through Modulating Gut Microbiome in Mice. Front Physiol. Oct 26;12:739174. doi: 10.3389/fphys.2021.739174. PMID: 34764881; PMCID: PMC8576288.

  12. Martins T, Barros AN, Rosa E, Antunes L. (2023). Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review. Molecules. Jul 11;28(14):5344. doi: 10.3390/molecules28145344. PMID: 37513218; PMCID: PMC10384064.

  13. Wang E, Wink M. (2016). Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan. PeerJ. Apr 7;4:e1879. doi: 10.7717/peerj.1879. PMID: 27077003; PMCID: PMC4830245.

  14. Lee SH, Kang HJ, Lee HJ, Kang MH, Park YK. (2010). Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers. Nutrition, 26(2), 175–183. https://doi.org/10.1016/j.nut.2009.03.010

  15. Nobel Prize Outreach AB 2024. (Dec. 2024). Presentation. NobelPrize.org. https://www.nobelprize.org/prizes/chemistry/1915/press-release/

  16. Howell Hughes J, Latner AL. (1936). Chlorophyll and haemoglobin regeneration after hemorrhage. Retrieved November 24, 2024, from https://pmc.ncbi.nlm.nih.gov/articles/PMC1394693/pdf/jphysiol01588-0057.pdf

  17. Zoneff E, Wang Y, Jackson C, Smith O, Duchi S, Onofrillo C, Farrugia B, Moulton SE, Williams R, Parish C, Nisbet DR, Caballero-Aguilar LM. (2024). Controlled oxygen delivery to power tissue regeneration. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-48719-x

  18. Weingarten M, Payson B. (1951). Deodorization of colostomies with chlorophyll. Rev Gastroenterol. Aug;18(8):602-4. PMID: 14864969.

  19. Young RW, Beregi JS Jr. (1980). Use of chlorophyllin in the care of geriatric patients. J Am Geriatr Soc. Jan;28(1):46-7. doi: 10.1111/j.1532-5415.1980.tb00124.x. PMID: 7350215.

  20. Yamazaki H, Fujieda M, Togashi M, Saito T, Preti G, Cashman JR, Kamataki T. (2004). Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients. Life Sci. Apr 16;74(22):2739-47. doi: 10.1016/j.lfs.2003.10.022. PMID: 15043988.

  21. Drugs and Lactation Database (LactMed®). Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Chlorella. 2021 Jun 21. PMID: 30000882.

  22. Uchiyama-Tanaka Y, Shimabukuro F, Okumura E, Fujishima M. (2023). The effect of Chlorella supplementation in pregnant women with low-grade inflammation. Food Sci Nutr. Oct 16;12(1):292-297. doi: 10.1002/fsn3.3759. PMID: 38268875; PMCID: PMC10804112.

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